Nnyocha serological nke Ọrịa Aka, Ụkwụ, na Ọnụ

Aka, Ụkwụ, na Ọnụ Ọrịa (HFMD).

Ọrịa Aka, Ụkwụ na Ọnụ na-agbasakarị n'etiti ụmụaka. Ọ na-efe efe nke ukwuu, nwere nnukwu ọrịa asymptomatic, ụzọ nnyefe dị mgbagwoju anya, na mgbasa ngwa ngwa, nwere ike ibute ntiwapụ nke ukwuu n'ime obere oge, na-eme ka njikwa ọrịa na-ama aka. N'oge ntiwapụ, ọrịa mkpokọta na ụlọ akwụkwọ ọta akara na ebe nlekọta ụmụaka, yana nchịkọta ezinụlọ nke ikpe nwere ike ime. Na 2008, Ministry of Health gụnyere HFMD na njikwa nke ọrịa na-efe efe nke Category C.

Coxsackievirus A16 (CA16) na Enterovirus 71 (EV71) bụ nje virus na-akpata HFMD. Ihe ndekọ ọrịa na-egosi na CA16 na-ekesakarị n'otu oge na EV71, na-eduga na ntiwapụ HFMD ugboro ugboro. N'oge ntiwapụ ndị a, ọnụ ọgụgụ nke ọrịa CA16 karịrị nke EV71, na-abụkarị ihe karịrị 60% nke ngụkọta ọrịa. HFMD nke EV71 kpatara nwere ike ibute mmebi sistemu ụjọ nke etiti. Ọnụ ọgụgụ nke ikpe siri ike na ọnụ ọgụgụ ikpe ọnwụ n'etiti ndị ọrịa bu EV71 dị elu nke ukwuu karịa ndị butere ọrịa enterovirus ndị ọzọ, yana ọnụ ọgụgụ ndị na-egbu egbu ruru 10%-25%. Agbanyeghị, ọrịa CA16 n'ozuzu anaghị ebute ọrịa dị iche iche metụtara sistemu ụjọ etiti dị ka meningitis aseptic, ụbụrụ ụbụrụ ụbụrụ, na poliomyelitis dị ka mkpọnwụ. Ya mere, nchoputa nke mbụ dị oke mkpa maka ịzọpụta ndụ ndị ikpe siri ike.

Nlele ụlọ ọgwụ

Nnwale ụlọ ọgwụ ugbu a maka HFMD bụ isi gụnyere nchọpụta nucleic acid nke pathogen na nchọpụta mgbochi serological. Ụlọ ọrụ Beier na-eji enzyme-njikọ immunosorbent assay (ELISA) na colloidal gold ụzọ ịzụlite Enterovirus 71 Antibody Test Kits na Coxsackievirus A16 IgM Antibody Test Kits maka nchọpụta dị iche iche nke HFMD pathogens. Nchọpụta ihe mgbochi serum na-enye nghọta dị elu, nkọwapụta dị mma, ma dị mfe, ngwa ngwa ma dabara adaba maka nnwale ụlọ ọgwụ na ụlọ ọrụ ahụike n'ọkwa niile yana maka nnukwu ọmụmụ onyunyo ọrịa na-efe efe.

Ihe ngosi achọpụtara akọwapụtara yana mkpa ụlọ ọgwụ gbasara ọrịa EV71

Nchoputa a kapịrị ọnụ nke ọrịa EV71 dabere na nchọpụta EV71-RNA, EV71-IgM, na EV71-IgG mgbochi n'ime ọbara, ma ọ bụ nchọpụta EV71-RNA na ụdị swab.

Na-esochi ọrịa EV71, ọgwụ mgbochi IgM na-apụta na mbụ, na-arị elu n'izu nke abụọ. Ọgwụ mgbochi IgG na-amalite ịpụta n'izu nke abụọ ka ọrịa butere ọrịa ma na-adịgide ruo ogologo oge. EV71-IgM bụ ihe dị mkpa na-egosi ọrịa mbụ ma ọ bụ na nso nso a, na-eme ka nchọpụta mmalite na ọgwụgwọ nke ọrịa EV71. EV71-IgG bụ isi ihe na-egosi nchoputa dị iche iche nke ọrịa, bara uru maka nyocha ọrịa na nyocha nke ịdị irè ịgba ọgwụ mgbochi ọrịa. Ịchọta mgbanwe na antibody titer n'etiti paited nnukwu na convalescent serum sample nwekwara ike ikpebi EV71 ọrịa ọnọdụ; dịka ọmụmaatụ, mmụba nke okpukpu anọ ma ọ bụ ka ukwuu nke geometric na antibody titer na convalescent serum ka e jiri ya tụnyere nnukwu serum nwere ike ikpebi dị ka ọrịa EV71 dị ugbu a.

Ihe ngosi achọpụtara akọwapụtara na mkpa ụlọ ọgwụ nke ọrịa CA16

Nchoputa a kapịrị ọnụ nke ọrịa CA16 na-adabere na nchọpụta CA16-RNA, CA16-IgM, na CA16-IgG antibodies na serum, ma ọ bụ nchọpụta CA16-RNA na ụdị swab.

Na-esochi ọrịa CA16, ọgwụ mgbochi IgM na-apụta na mbụ, na-arị elu n'izu nke abụọ. Ọgwụ mgbochi IgG na-amalite ịpụta n'izu nke abụọ ka ọrịa butere ọrịa ma na-adịgide ruo ogologo oge. CA16-IgM bụ ihe dị mkpa na-egosi ọrịa mbụ ma ọ bụ na nso nso a.

Mkpa nke Ngwakọta EV71 na CA16 Antibody Test

A na-akpata HFMD site na ọtụtụ enteroviruses, yana serotypes nkịtị bụ EV71 na CA16. Nnyocha na-egosi na HFMD nke nje CA16 kpatara na-enyekarị akara ngosi dịtụ iche, nwere nsogbu ole na ole, yana prognosis dị mma. N'ụzọ dị iche, HFMD nke EV71 kpatara na-ebutekarị mgbaàmà ụlọ ọgwụ siri ike karị, na-enwe ọnụ ọgụgụ dị elu nke ikpe siri ike na ikpe ọnwụ, na-ejikọta ya na nsogbu usoro nhụjuanya nke etiti. Mgbaàmà nke ụlọ ọgwụ nke HFMD dị mgbagwoju anya ma na-enwekarị ụdị, na-eme nchọpụta ahụike siri ike, karịsịa na mmalite mmalite. Ihe dị n'iji nnwale ọbara jikọtara ọnụ na-adabere n'iji dochie ụzọ mgbochi nje na-ewe oge na nke siri ike, na-achọpụta nje nje na serologically, na inye ihe ndabere maka nyocha ụlọ ọgwụ, usoro ọgwụgwọ, na amụma ọrịa.

Nyocha arụmọrụ ngwaahịa

EV71-IgM ELISAKitNyocha arụmọrụ

Nsonaazụ na-egosi:Ngwa nnwale Beier EV71-IgM na-egosipụta mmetụta dị elu yana ezigbo nkọwa maka nnwale ọbara sitere na ndị bu EV71. Ebe data: National Institute for Viral Control and Prevention, Chinese CDC.

Nyocha arụmọrụ Kit EV71-IgG ELISA (I)

Nyocha arụmọrụ ngwa EV71-IgG ELISA (II)

Nsonaazụ na-egosi:Ngwa nnwale Beier EV71-IgG na-egosipụta ọnụọgụ nchọpụta dị elu maka ọbara sitere na ndị mmadụ na-ebute ọrịa EV71 ugboro ugboro. Ebe data: National Institute for Viral Control and Prevention, Chinese CDC.

Nyocha arụmọrụ Kit CA16-IgM ELISA

Nsonaazụ na-egosi:Ngwa ule Beier CA16-IgM na-egosiputa ọnụọgụ nchọpụta dị elu na nkwenye dị mma. Ebe data: National Institute for Viral Control and Prevention, Chinese CDC.

Ngwa nyocha EV71-IgM (Colloidal Gold) Nyocha arụmọrụ

Nsonaazụ na-egosi:Ngwa nnwale Beier EV71-IgM (Colloidal Gold) na-egosipụta mmetụta dị elu na nkọwapụta dị mma maka nnwale ọbara sitere na ndị bu EV71. Ebe data: National Institute for Viral Control and Prevention, Chinese CDC.

Ngwa nyocha CA16-IgM (Colloidal Gold) Nyocha arụmọrụ

Nsonaazụ na-egosi:The Beier CA16-IgM Test Kit (Colloidal Gold) na-egosipụta mmetụta dị elu na nkọwa dị mma maka ịchọpụta serum sitere na ndị nwere CA16 bu ọrịa. Ebe data: National Institute for Viral Control and Prevention, Chinese CDC.